Achieving High Affinity for a Bacterial Lectin with Reversible Covalent Ligands
Giulia Antonini, Anna Bernardi, Emile Gillon, Alberto Dal Corso, Monica Civera, Laura Belvisi, Annabelle Varrot and Sarah Mazzotta J. Med. Chem. 2024, 67, 19546−19560 High-affinity monovalent ligands for lectins are challenging to develop due to weak binding interactions. This study investigates the potential of rationally designed covalent ligands targeting the N-terminal domain of BC2L-C lectin … Read more