Month: November 2024
Achieving High Affinity for a Bacterial Lectin with Reversible Covalent Ligands
Giulia Antonini, Anna Bernardi, Emile Gillon, Alberto Dal Corso, Monica Civera, Laura Belvisi, Annabelle Varrot and Sarah Mazzotta J. Med. Chem. 2024, 67, 19546−19560 High-affinity monovalent ligands for lectins are challenging to develop due to weak binding interactions. This study investigates the potential of rationally designed covalent ligands targeting the N-terminal domain of BC2L-C lectin … Read more
Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells
Andrea Citarella, Serena Petrella, Davide Moi, Alessandro Dimasi, Tommaso Braga, Lorenzo Ruberto, Stefano Pieraccini, Maurizio Sironi, Nicola Micale, Tanja Schirmeister, Giovanna Damia, Valerio Fasano, Alessandra Silvani, Clelia Giannini, Daniele Passarella
Bioorganic & Medicinal Chemistry, 117987, 2024
Peptide Nucleic Acids in Saturation Transfer Difference Nuclear Magnetic Resonance Experiments: A Simple and Valuable Tool for Studying HuR–Small Molecule Complexes
rene Gado, Martina Garbagnoli, Francesca Alessandra Ambrosio, Roberta Listro, Michela Parafioriti, Silvia Cauteruccio, Daniela Rossi, Pasquale Linciano, Giosuè Costa, Stefano Alcaro, Francesca Vasile, Simona Collina
ACS Omega, ASAP