Francesco Migliano, Luca Pozzi, Andrea Citarella, Giovanni Macetti, Leonardo Lo Presti, Daniele Passarella, Valerio Fasano
🔬Planar chirality meets NMR spectroscopy!
N-carbonyl bispidines are a compelling example of molecules that display planar chirality, existing as two enantiomers (Rp and Sp).
When the rotation of the carbonyl group is slower than the NMR timescale, desymmetrization of the NMR signals is observed — a clear indication of conformational dynamics at play. ✨
A striking demonstration of how molecular structure and spectroscopic techniques reveal subtle dynamic behavior.
🔍Full study now published in Organic Letters:
https://pubs.acs.org/doi/10.1021/acs.orglett.5c02839