Martina Pedrini, Luca Pozzi, Francesca Sacchi, Andrea Citarella, Valerio Fasano, Pierfausto Seneci, Stefano Pieraccini, Lorenzo Ruberto, Helena Perez Peña, Alfredo Garzino-Demo, Adriana Vitiello, Leonardo Sernicola, Alessandra Borsetti, Arianna Calistri, Cristina Parolin, Daniele Passarella

Bioorganic & Medicinal Chemistry Volume 121, 15 April 2025, 118124

Novel bivalent compounds, combining bile acids and triterpenoids natural products derivatives, can bind to two distinct pockets of the SARS-CoV-2 Spike protein. This dual targeting enhances antiviral activity against pseudotyped lentiviruses while potentially reducing side effects. 🧬🦠

#COVID19Research #SpikeProtein #AntiviralCompounds #BivalentMolecules #DrugDiscovery #organicchemistry #naturalproducts