Month: February 2025
Design, synthesis and in vitro validation of bivalent binders of SARS-CoV-2 spike protein: Obeticholic, betulinic and glycyrrhetinic acids as building blocks
Martina Pedrini, Luca Pozzi, Francesca Sacchi, Andrea Citarella, Valerio Fasano, Pierfausto Seneci, Stefano Pieraccini, Lorenzo Ruberto, Helena Perez Peña, Alfredo Garzino-Demo, Adriana Vitiello, Leonardo Sernicola, Alessandra Borsetti, Arianna Calistri, Cristina Parolin, Daniele Passarella Bioorganic & Medicinal Chemistry Volume 121, 15 April 2025, 118124 Novel bivalent compounds, combining bile acids and triterpenoids natural products derivatives, can bind … Read more
Revisiting the Reduction of Vinpocetine
Simone Borsoi, Luca Pozzi, Valerio Fasano, Andrea Citarella, Giovanni Macetti, Leonardo Lo Presti, Giuseppe Paladino, Umberto Ciriello, Daniele Passarella ChemistrySelect 2025, 10, e202406175 Hydrogenation of the semisynthetic vinca alkaloid vinpocetine produces two epimers that have previously been investigated as chiral additives. However, the absence of a full characterization generated some ambiguities in their stereochemical identification. In this study, computational methods, NMR analysis, and X-ray crystallography … Read more